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Microglial responses around intrinsic CNS neurons are correlated with axonal regeneration

Shokouhi, B.N.; Wong, B.Z.Y.; Siddiqui, S.; Lieberman, A.R.; Campbell, G.; Tohyama, K.; Anderson, P.N.; (2010) Microglial responses around intrinsic CNS neurons are correlated with axonal regeneration. BMC Neuroscience , 11 , Article 13. 10.1186/1471-2202-11-13. Green open access

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Background: Microglia/macrophages and lymphocytes (T-cells) accumulate around motor and primary sensory neurons that are regenerating axons but there is little or no microglial activation or T-cell accumulation around axotomised intrinsic CNS neurons, which do not normally regenerate axons. We aimed to establish whether there was an inflammatory response around the perikarya of CNS neurons that were induced to regenerate axons through a peripheral nerve graft. Results: When neurons of the thalamic reticular nucleus (TRN) and red nucleus were induced to regenerate axons along peripheral nerve grafts, a marked microglial response was found around their cell bodies, including the partial enwrapping of some regenerating neurons. T-cells were found amongst regenerating TRN neurons but not rubrospinal neurons. Axotomy alone or insertion of freeze-killed nerve grafts did not induce a similar perineuronal inflammation. Nerve grafts in the corticospinal tracts did not induce axonal regeneration or a microglial or T-cell response in the motor cortex. Conclusions: These results strengthen the evidence that perineuronal microglial accumulation (but not T-cell accumulation) is involved in axonal regeneration by intrinsic CNS and other neurons.

Type: Article
Title: Microglial responses around intrinsic CNS neurons are correlated with axonal regeneration
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2202-11-13
Publisher version: http://dx.doi.org/10.1186/1471-2202-11-13
Language: English
Additional information: © 2010 Shokouhi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/20024
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