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Intravital Imaging Illuminates Transforming Growth Factor β Signaling Switches during Metastasis

Giampieri, S; Pinner, S; Sahai, E; (2010) Intravital Imaging Illuminates Transforming Growth Factor β Signaling Switches during Metastasis. [Review]. Cancer Research , 70 (9) pp. 3435-3439. 10.1158/0008-5472.CAN-10-0466. Green open access

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Abstract

Transforming growth factor β (TGFβ) has seemingly contradictory roles in tumor progression: it can promote metastatic invasion but also act as a tumor suppressor. Recently, two studies have used intravital imaging to unravel the role of TGFβ at different stages of the metastatic process. TGFβ promotes single cell motility, which enables invasion into blood vessels. However the activation of TGFβ signaling is a transient event and is not maintained at distant sites. The downregulation of TGFβ signaling at secondary sites then permits growth of secondary tumors. In the absence of TGFβ, cells are restricted to collective movement and lymphatic spread. Here, we discuss these findings and their potential implications.

Type: Article
Title: Intravital Imaging Illuminates Transforming Growth Factor β Signaling Switches during Metastasis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1158/0008-5472.CAN-10-0466
Publisher version: https://doi.org/10.1158/0008-5472.CAN-10-0466
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Animals, Cell Movement, Humans, Molecular Imaging, Neoplasm Metastasis, Neoplasms, Signal Transduction, Transforming Growth Factor beta
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/191525
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