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APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample

Hubacek, J.A.; Peasey, A.; Pikhart, H.; Stavek, P.; Kubinova, R.; Marmot, M.; Bobak, M.; (2010) APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample. Human Immunology , 71 (3) pp. 304-308. 10.1016/j.humimm.2010.01.008. Green open access

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Abstract

The literature on association between apolipoprotein E (APOE) gene variations and plasma levels of C-reactive protein (CRP) remains inconsistent, mainly due to low statistical power of previous studies. To clarify this question, we analysed data from large population sample of randomly selected individuals from 7 Czech towns (2886 males and 3344 females, the HAPIEE study). In both males and females, the lowest levels of plasma hsCRP were observed in the carriers of the APOE ε4ε4 and ε4ε3 genotypes. The median (inter-quartile range, IQR) concentration of hsCRP in carriers of the most common APOE ε3ε3 genotype (two thirds of participants) was 1.13 (IQR 0.56; 2.33) mg/l in men and 1.23 (IQR 0.61; 2.65) mg/l in women, compared with 0.72 (IQR 0.61; 0.86) mg/l in male and 0.72 (IQR 0.61-0.85) mg/l in female carriers of APOE ε4ε3/ε4ε4 genotypes; the differences were statistically significant (p<0.001). The association between APOE and CRP was not materially affected by adjustment for age, sex, history of cardiovascular disease or cardiovascular risk factors. This study, the largest to date, provides robust evidence of an association between plasma hsCRP and the APOE genotype, an association not explained by history of cardiovascular disease nor its risk factors.

Type: Article
Title: APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.humimm.2010.01.008
Publisher version: http://dx.doi.org/10.1016/j.humimm.2010.01.008
Language: English
Keywords: APOE, C-reactive protein, Polymorphism, Population study, inflammation, APOLIPOPROTEIN-E POLYMORPHISM, E GENOTYPE, CARDIOVASCULAR RISK, CRP CONCENTRATION, DISEASE, ASSOCIATION, HERITABILITY, EXPRESSION, MORTALITY, HYPERLIPIDEMIA
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/19002
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