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Glial and axonal body fluid biomarkers are related to infarct volume, severity, and outcome.

Petzold, A; Michel, P; Stock, M; Schluep, M; (2008) Glial and axonal body fluid biomarkers are related to infarct volume, severity, and outcome. J Stroke Cerebrovasc Dis , 17 (4) pp. 196-203. 10.1016/j.jstrokecerebrovasdis.2008.02.002. Green open access

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Abstract

Body fluid biomarkers of central nervous system damage may help improve the prognostic and diagnostic accuracy in ischemic stroke. We studied 53 patients. Stroke severity and outcome was rated using the National Institutes of Health Stroke Scale and modified Rankin scale. Ferritin, S100B, and NfH were measured in cerebrospinal fluid (CSF) and serum. Infarct volume was calculated from T2W images. CSF S100B (median 1.00 ng/mL) and CSF ferritin (10.0 ng/mL) levels were elevated in patients with stroke compared with control subjects (0.62 ng/mL, P < .0001; 2.34 ng/mL, P < .0001). Serum S100B (0.09 ng/mL) was higher in patients with stroke compared with control subjects (0.01 ng/mL). CSF S100B levels were higher in patients with a cardioembolic stroke (2.88 ng/mL) than in those with small-vessel disease (0.89 ng/mL, P < .05). CSF S100B levels correlated with the National Institutes of Health Stroke Scale score on admission (R = 0.56, P < .01) and the stroke volume (R = 0.44, P = .01). CSF S100B and NfH-SMI35 levels correlated with outcome on the modified Rankin scale. CSF S100B levels were related to stroke severity and infarct volume and highest in cardioembolic stroke.

Type: Article
Title: Glial and axonal body fluid biomarkers are related to infarct volume, severity, and outcome.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jstrokecerebrovasdis.2008.02.002
Keywords: Adult, Axons, Biomarkers, Brain, Brain Damage, Chronic, Brain Ischemia, Cerebral Infarction, Female, Ferritins, Heart Diseases, Humans, Intracranial Arteriosclerosis, Intracranial Embolism, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Growth Factors, Nerve Tissue Proteins, Neurofilament Proteins, Neuroglia, Prospective Studies, S100 Calcium Binding Protein beta Subunit, S100 Proteins, Severity of Illness Index, Single-Blind Method
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/18892
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