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Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women

Jefferis, B.J.; Whincup, P.; Welsh, P.; Wannamethee, G.; Rumley, A.; Lennon, L.; Thomson, A.; ... Lowe, G.; + view all (2010) Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women. Atherosclerosis , 208 (2) pp. 557-563. 10.1016/j.atherosclerosis.2009.08.018. Green open access

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Abstract

OBJECTIVES: The endopeptidase matrix metalloproteinase-9 (MMP-9) is implicated in atherosclerotic plaque rupture. We investigate prospective associations between MMP-9 and MI or stroke in an older general population cohort, accounting for established and novel cardiovascular risk factors. METHODS: Baseline serum MMP-9 was measured in incident MI (n=368) and stroke (n=299) cases and two controls per case, 'nested' in prospective studies of 4252 men and 4286 women aged 60-79 years, sampled from General Practices in Britain in 1998-2000, with 7-year follow-up for fatal and non-fatal MI and stroke. RESULTS: Geometric mean MMP-9 was 528ng/mL (IQR 397, 743) in MI cases compared to 501ng/mL (IQR 370, 743) in controls, p=0.10. Participants in the top compared to bottom third of MMP-9 levels had an age-adjusted odds ratio for MI of 1.53 (95% CI 1.09, 2.13), which attenuated to 1.18 (95% CI 0.81, 1.70) after adjustment for established and novel cardiovascular risk factors. There was weak evidence that OR differed according to pre-existing CVD; the OR for MI in 187 participants with pre-existing CVD was 2.20 (1.04, 4.64) and 1.24 (0.84, 1.82) in 715 participants without (LR test for interaction p=0.06). Geometric mean MMP-9 levels were higher in stroke cases than controls; 522ng/mL (IQR 363, 673) vs 487 (IQR 393, 704), p=0.045; however adjustments similarly attenuated the associations. CONCLUSIONS: While serum MMP-9 is univariately associated with risk of MI and stroke, it is not a strong independent risk marker for either.

Type: Article
Title: Prospective study of matrix metalloproteinase-9 and risk of myocardial infarction and stroke in older men and women
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.atherosclerosis.2009.08.018
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC282295...
Language: English
Keywords: Myocardial infarction, Stroke, Inflammation, Epidemiology, MMP-9, Prospective, Cohort, CORONARY-ARTERY-DISEASE, CARDIOVASCULAR-DISEASE, PLASMA MATRIX-METALLOPROTEINASE-9, SERUM MATRIX-METALLOPROTEINASE-9, MATRIX METALLOPROTEINASES, HEART-DISEASE, SUSCEPTIBILITY, LEVEL
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/18274
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