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Photodynamic therapy of malignant and premalignant lesions in patients with ’field cancerization‘ of the oral cavity

Grant, WE; Hopper, C; Speight, PM; Path, MRC; Macrobert, AJ; Bown, SG; (1993) Photodynamic therapy of malignant and premalignant lesions in patients with ’field cancerization‘ of the oral cavity. Journal of Laryngology and Otology , 107 (12) 1140 - 1145. 10.1017/S0022215100125496. Green open access

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Abstract

The management of patients with 'field cancerization' of the oral mucosa. with multicentric foci of invasion, presents a considerable problem for the head and neck surgeon. Surgical resection of synchronous or metachronous primary squamous cell carcinomas, along with adjacent premalignant lesions, is likely to be associated with considerable mutilation. Photodynamic therapy (PDT) has been shown to be of value in the treatment of superficial tumours in the upper aerodigestive tract, with excellent healing of treated areas. This study reports the use of PDT to treat 11 patients with 'field cancerization' occurring in the oral cavity. Six 'patients had multiple primary cancers and five had single primary tumours. All had associated areas of leukoplakia. Each received Photofrin 2 mg/kg 48 hours prior to photoirradiation with 50-100 J/cm2 red laser light by surface illumination. Six to eight weeks later treated areas in 10 of the 11 patients showed a complete response to PDT; one patient had areas of residual leukoplakia. Two patients developed further areas of leukoplakia or erythroplakia within 12 months but no patient has had evidence of recurrent invasive carcinoma in the treated areas. Longer term follow-up will be necessary to exclude further recurrence. It is concluded that PDT offers an effective repeatable treatment option, whether on its own or as an adjunct to local excision, for patients with 'field cancerization' of the oral cavity.

Type: Article
Title: Photodynamic therapy of malignant and premalignant lesions in patients with ’field cancerization‘ of the oral cavity
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0022215100125496
Publisher version: http://dx.doi.org/10.1017/S0022215100125496
Language: English
Additional information: Copyright Cambridge University Press 1993
Keywords: Photodynamic therapy, Head and neck neoplasms, Head, Neck, Cancer, Phthalocyanine, Leukoplakia, Transformation, Neoplasms, Carcinoma, Tissues, Skin
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > EDI MaxFac, Diagnostic, Med and Surg Sci
URI: https://discovery.ucl.ac.uk/id/eprint/178911
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