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Ovarian Cancer: A Clinical Challenge That Needs Some Basic Answers

Lawrenson, K; Gayther, SA; (2009) Ovarian Cancer: A Clinical Challenge That Needs Some Basic Answers. PLoS Medicine , 6 (2) , Article e1000025. 10.1371/journal.pmed.1000025. Green open access

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Abstract

From a clinical perspective, epithelial ovarian cancer is something of an enigma. Despite improvements in aggressive debulking surgery and the initial good response of patients to platinum-based chemotherapies, there has been little improvement in the survival rates for over three decades. About 65% of women with epithelial ovarian cancer will die within five years of their diagnosis [1]. Early-stage ovarian cancers are often asymptomatic and the recognised signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease, and it seems unlikely that symptoms alone could help to improve the proportion of tumours that are diagnosed at earlier, more treatable stages. Unfortunately, there are no effective biomarkers that can identify early-stage disease and no reliable prognostic markers for predicting clinical response and guiding treatment regimes. Furthermore, there remains intense debate about the cellular origins, precursor lesions, and histological classification of the disease. With so many unknowns, it is perhaps not surprising that progress in reducing mortality in women diagnosed with ovarian cancer has been so limited.

Type: Article
Title: Ovarian Cancer: A Clinical Challenge That Needs Some Basic Answers
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pmed.1000025
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC263479...
Language: English
Additional information: © 2009 Lawrenson and Gayther. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: NEGATIVE BREAST-CANCER, PROGNOSTIC SIGNATURE, EXPRESSION, VALIDATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/175134
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