UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Genome-wide linkage scan on estimated breeding values for a quantitative trait

Zabaneh, D; Mackay, IJ; (2003) Genome-wide linkage scan on estimated breeding values for a quantitative trait. BMC GENETICS , 4 , Article S61. 10.1186/1471-2156-4-S1-S61. Green open access

[thumbnail of 1471-2156-4-S1-S61.pdf]
Preview
PDF
1471-2156-4-S1-S61.pdf

Download (350kB)

Abstract

Background: A genome-wide linkage scan was performed on Replicate 1 of the simulated data for fasting triglyceride levels. The aim of this study was to implement mixed-model methodology to estimate breeding values for each individual for this trait and to assess the merit of these breeding values in linkage analysis. These breeding values utilize all the pedigree information, and the genetic and phenotypic correlations with other measured traits across the two cohorts. A genome-wide linkage scan was run on both the new breeding value traits and the original traits.Results: Using breeding values, a maximum LOD of 7.78 was found on chromosome 5 at a position very close to a gene underlying the triglyceride levels. This effect was not detected using the original trait.Conclusion: The results imply that estimating breeding values may be a suitable method of deriving traits for use in genome-wide scans.

Type: Article
Title: Genome-wide linkage scan on estimated breeding values for a quantitative trait
Location: NEW ORLEANS, LOUISIANA
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2156-4-S1-S61
Publisher version: http://dx.doi.org/10.1186/1471-2156-4-S1-S61
Language: English
Additional information: © 2003 Zabaneh and Mackay; licensee BioMed Central Ltd
Keywords: Chromosome Mapping, Chromosomes, Human, Pair 18, Chromosomes, Human, Pair 5, Chromosomes, Human, Pair 7, Cohort Studies, Computer Simulation, Fasting, Female, Genetic Linkage, Genetic Testing, Genome, Human, Humans, Lod Score, Longitudinal Studies, Male, Models, Genetic, Pedigree, Phenotype, Quantitative Trait, Heritable, Triglycerides
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/168252
Downloads since deposit
97Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item