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Troponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study

O'Hanlon, R; Wilson, M; Wage, R; Smith, G; Alpendurada, FD; Wong, J; Dahl, A; ... Prasad, SK; + view all (2010) Troponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study. Journal of Cardiovascular Magnetic Resonance , 12 , Article 38. 10.1186/1532-429X-12-38. Green open access

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Abstract

Background: The aetiology and clinical significance of troponin release following endurance exercise is unclear but may be due to transient myocardial inflammation. Cardiovascular magnetic resonance (CMR) affords us the opportunity to evaluate the presence of myocardial inflammation and focal fibrosis and is the ideal imaging modality to study this hypothesis. We sought to correlate the relationship between acute bouts of ultra endurance exercise leading to cardiac biomarkers elevation and the presence of myocardial inflammation and fibrosis using CMR.Methods: 17 recreation athletes (33.5 +/- 6.5 years) were studied before and after a marathon run with troponin, NTproBNP, and CMR. Specific imaging parameters to look for inflammation included T2 weighted images, and T1 weighted spin-echo images before and after an intravenous gadolinium-DTPA to detect myocardial hyperemia secondary to inflammation. Late gadolinium imaging was performed (LGE) to detect any focal regions of replacement fibrosis.Results: Eleven of the 17 participant had elevations of TnI above levels of cut off for myocardial infarction 6 hrs after the marathon (0.075 +/- 0.02, p = 0.007). Left ventricular volumes were reduced post marathon and a small increase in ejection fraction was noted (64 +/- 1% pre, 67 +/- 1.2% post, P = 0.014). Right ventricular volumes, stroke volume, and ejection fraction were unchanged post marathon. No athlete fulfilled criteria for myocardial inflammation based on current criteria. No regions of focal fibrosis were seen in any of the participants.Conclusion: Exercise induced cardiac biomarker release is not associated with any functional changes by CMR or any detectable myocardial inflammation or fibrosis.

Type: Article
Title: Troponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1532-429X-12-38
Publisher version: http://dx.doi.org/10.1186/1532-429X-12-38
Language: English
Additional information: © 2010 O'Hanlon et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: LEFT-VENTRICULAR HYPERTROPHY, MYOCARDIAL-INFARCTION, PROLONGED EXERCISE, T RELEASE, HEART, DYSFUNCTION, MARATHON, HUMANS, METAANALYSIS, RUNNERS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > CRUK Cancer Trials Centre
URI: https://discovery.ucl.ac.uk/id/eprint/166330
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