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Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells

Schwarz, Q; Vieira, JM; Howard, B; Eickholt, BJ; Ruhrberg, C; (2008) Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells. DEVELOPMENT , 135 (9) 1605 - 1613. 10.1242/dev.015412. Green open access

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Abstract

Neuropilin (NRP) receptors and their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth cone guidance of peripherally projecting nerves. Here we report that loss of NRP1 or NRP2 also impairs sensory neuron positioning in the mouse head, and that this defect is a consequence of inappropriate cranial neural crest cell migration. Specifically, neural crest cells move into the normally crest-free territory between the trigeminal and hyoid neural crest streams and recruit sensory neurons from the otic placode; these ectopic neurons then extend axons between the trigeminal and facioacoustic ganglia. Moreover, we found that NRP1 and NRP2 cooperate to guide cranial neural crest cells and position sensory neurons; thus, in the absence of SEMA3/NRP signalling, the segmentation of the cranial nervous system is lost. We conclude that neuropilins play multiple roles in the sensory nervous system by directing cranial neural crest cells, positioning sensory neurons and organising their axonal projections.

Type: Article
Title: Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/dev.015412
Publisher version: http://ukpmc.ac.uk/abstract/MED/18356247
Keywords: neural crest cell, placode, peripheral nervous system, sensory neuron, axon guidance, neuropilin, semaphorin, mouse, PERIPHERAL-NERVE PROJECTION, SENSORY NEURONS, NEUROGENIC PLACODES, NEUREGULIN RECEPTOR, HINDBRAIN REGION, MICE LACKING, IN-VIVO, MIGRATION, CHICK, EXPRESSION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/16402
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