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Borate esters: Simple catalysts for the sustainable synthesis of complex amides

Sabatini, MT; Boulton, LT; Sheppard, TD; (2017) Borate esters: Simple catalysts for the sustainable synthesis of complex amides. Science Advances , 3 (9) , Article e1701028. 10.1126/sciadv.1701028. Green open access

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Abstract

Chemical reactions for the formation of amide bonds are among the most commonly used transformations in organic chemistry, yet they are often highly inefficient. A novel protocol for amidation using a simple borate ester catalyst is reported. The process presents significant improvements over other catalytic amidation methods in terms of efficiency and safety, with an unprecedented substrate scope including functionalized heterocycles and even unprotected amino acids. The method was used to access a wide range of functionalized amide derivatives, including pharmaceutically relevant targets, important synthetic intermediates, a catalyst, and a natural product.

Type: Article
Title: Borate esters: Simple catalysts for the sustainable synthesis of complex amides
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/sciadv.1701028
Publisher version: http://doi.org/10.1126/sciadv.1701028
Language: English
Additional information: Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1576531
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