Scahill, RI;
Andre, R;
Tabrizi, SJ;
Aylward, EH;
(2017)
Structural imaging in premanifest and manifest Huntington disease.
In: Feigin, AS and Anderson, KE, (eds.)
Handbook of Clinical Neurology.
(pp. 247-261).
Elsevier: Amsterdam, Netherlands.
![[thumbnail of 2017 Handbook Clin Neurol Structural imaging in pre and HD (Scahill).pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/text.png) |
Text
2017 Handbook Clin Neurol Structural imaging in pre and HD (Scahill).pdf Access restricted to UCL open access staff Download (1MB) |
Abstract
Huntington disease (HD) neuropathology has a devastating effect on brain structure and consequently brain function; neuroimaging provides a means to assess these effects in gene carriers. In this chapter we first outline the unique utility of structural imaging in understanding HD and discuss some of the acquisition and analysis techniques currently available. We review the existing literature to summarize what we know so far about structural brain changes across the spectrum of disease from premanifest through to manifest disease. We then consider how these neuroimaging findings relate to patient function and nonimaging biomarkers, and can be used to predict disease onset. Finally we review the utility of imaging measures for assessment of treatment efficacy in clinical trials.
| Type: | Book chapter |
|---|---|
| Title: | Structural imaging in premanifest and manifest Huntington disease |
| DOI: | 10.1016/B978-0-12-801893-4.00020-1 |
| Publisher version: | https://doi.org/10.1016/B978-0-12-801893-4.00020-1 |
| Language: | English |
| Keywords: | Huntington disease, MRI, biomarker, cortex, striatum, volumetric, white matter, Brain, Heterozygote, Humans, Huntington Disease, Neuroimaging |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1576527 |
Archive Staff Only
 |
View Item |
