Keane, MG;
Shah, A;
Pereira, SP;
Joshi, D;
(2017)
Novel biomarkers and endoscopic techniques for diagnosing pancreaticobiliary malignancy.
F1000Research
, 6
, Article 1643. 10.12688/f1000research.11371.1.
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Abstract
The UK incidence of pancreatic ductal adenocarcinoma is 9 per 100,000 population, and biliary tract cancer occurs at a rate of 1-2 per 100,000. The incidence of both cancers is increasing annually and these tumours continue to be diagnosed late and at an advanced stage, limiting options for curative treatment. Population-based screening programmes do not exist for these cancers, and diagnosis currently is dependent on symptom recognition, but often symptoms are not present until the disease is advanced. Recently, a number of promising blood and urine biomarkers have been described for pancreaticobiliary malignancy and are summarised in this review. Novel endoscopic techniques such as single-operator cholangioscopy and confocal endomicroscopy have been used in some centres to enhance standard endoscopic diagnostic techniques and are also evaluated in this review.
| Type: | Article |
|---|---|
| Title: | Novel biomarkers and endoscopic techniques for diagnosing pancreaticobiliary malignancy |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.12688/f1000research.11371.1 |
| Publisher version: | http://doi.org/10.12688/f1000research.11371.1 |
| Language: | English |
| Additional information: | © 2017 Keane MG et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | CA 19-9, Endoscopic retrograde, Pancreaticobiliary malignancy, biliary, cholangiopancreatography, pancreatic |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1576368 |
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