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Modulation of spike-evoked synaptic transmission: The role of presynaptic calcium and potassium channels

Rama, S; Zbili, M; Debanne, D; (2014) Modulation of spike-evoked synaptic transmission: The role of presynaptic calcium and potassium channels. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research , 1853 (9) pp. 1933-1939. 10.1016/j.bbamcr.2014.11.024. Green open access

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Abstract

Action potentials are usually considered as the smallest unit of neuronal information conveyed by presynaptic neurons to their postsynaptic target. Thus, neuronal signaling in brain circuits is all-or-none or digital. However, recent studies indicate that subthreshold analog variation in presynaptic membrane potential modulates spike-evoked transmission. The informational content of each presynaptic action potential is therefore greater than initially expected. This property constitutes a form of fast activity-dependent modulation of functional coupling. Therefore, it could have important consequences on information processing in neural networks in parallel with more classical forms of presynaptic short-term facilitation based on repetitive stimulation, modulation of presynaptic calcium or modifications of the release machinery. We discuss here how analog voltage shift in the presynaptic neuron may regulate spike-evoked release of neurotransmitter through the modulation of voltage-gated calcium and potassium channels in the axon and presynaptic terminal. This article is part of a Special Issue entitled: 13th European Symposium on Calcium.

Type: Article
Title: Modulation of spike-evoked synaptic transmission: The role of presynaptic calcium and potassium channels
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbamcr.2014.11.024
Publisher version: https://doi.org/10.1016/j.bbamcr.2014.11.024
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Calcium channel, Cav2.1, Potassium channel, Kv1, Synaptic transmission, Axon
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/1575784
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