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Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders

Clouston, S; Pietrzak, RH; Kotov, R; Richards, M; Spiro III, A; Scott, S; Deri, Y; ... Luft, BJ; + view all (2017) Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders. Alzheimer's & Dementia: Translational Research and Clinical Interventions , 3 (4) pp. 593-602. 10.1016/j.trci.2017.09.001. Green open access

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Abstract

Introduction: This study examined whether World Trade Center (WTC)-related exposures and posttraumatic stress disorder (PTSD) were associated with cognitive function and whether WTC responders' cognition differed from normative data. / Methods: A computer-assisted neuropsychological battery was administered to a prospective cohort study of 1193 WTC responders with no history of stroke or WTC-related head injuries. Data were linked to information collected prospectively since 2002. Sample averages were compared to published norms. / Results: Approximately 14.8% of sampled responders had cognitive dysfunction. WTC responders had worse cognitive function compared to normative data. PTSD symptom severity and working >5 weeks on-site was associated with cognitive dysfunction. / Discussion: Results from this sample highlight the potential for WTC responders to be experiencing an increased burden of cognitive dysfunction and linked lowered cognitive functioning to physical exposures and to PTSD. Future research is warranted to understand the extent to which cognitive dysfunction is evident in neural dysfunction.

Type: Article
Title: Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.trci.2017.09.001
Publisher version: https://doi.org/10.1016/j.trci.2017.09.001
Language: English
Additional information: Copyright © 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: World Trade Center, Cognitive dysfunction, Trauma, Particulate exposure, Posttraumatic stress disorder
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
URI: https://discovery.ucl.ac.uk/id/eprint/1575767
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