Rama, S;
Zbili, M;
Fékété, A;
Tapia, M;
Benitez, MJ;
Boumedine, N;
Garrido, JJ;
(2017)
The role of axonal Kv1 channels in CA3 pyramidal cell excitability.
Scientific Reports
, 7
, Article 315. 10.1038/s41598-017-00388-1.
Preview |
Text (Published version of record)
s41598-017-00388-1.pdf - Published Version Download (3MB) | Preview |
Preview |
Text (Supplementary data)
Rama_Role_axonal_Kv1_Suppl.pdf Download (427kB) | Preview |
Abstract
Axonal ion channels control spike initiation and propagation along the axon and determine action potential waveform. We show here that functional suppression of axonal Kv1 channels with local puff of dendrotoxin (DTx), laser or mechanical axotomy significantly increased excitability measured in the cell body. Importantly, the functional effect of DTx puffing or axotomy was not limited to the axon initial segment but was also seen on axon collaterals. In contrast, no effects were observed when DTx was puffed on single apical dendrites or after single dendrotomy. A simple model with Kv1 located in the axon reproduced the experimental observations and showed that the distance at which the effects of axon collateral cuts are seen depends on the axon space constant. In conclusion, Kv1 channels located in the axon proper greatly participate in intrinsic excitability of CA3 pyramidal neurons. This finding stresses the importance of the axonal compartment in the regulation of intrinsic neuronal excitability.
| Type: | Article |
|---|---|
| Title: | The role of axonal Kv1 channels in CA3 pyramidal cell excitability |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41598-017-00388-1 |
| Publisher version: | http://dx.doi.org/10.1038/s41598-017-00388-1 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1575766 |
Archive Staff Only
 |
View Item |
