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Elements of the niche for adult stem cell expansion

Redondo, PA; Pavlou, M; Loizidou, M; Cheema, U; (2017) Elements of the niche for adult stem cell expansion. Journal of Tissue Engineering , 8 pp. 1-18. 10.1177/2041731417725464. Green open access

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Abstract

Adult stem cells are crucial for tissue homeostasis. These cells reside within exclusive locations in tissues, termed niches, which protect adult stem cell fidelity and regulate their many functions through biophysical-, biochemical- and cellular-mediated mechanisms. There is a growing understanding of how these mechanisms and their components contribute towards maintaining stem cell quiescence, self-renewal, expansion and differentiation patterns. In vitro expansion of adult stem cells is a powerful tool for understanding stem cell biology, and for tissue engineering and regenerative medicine applications. However, it is technically challenging, since adult stem cell removal from their native microenvironment has negative repercussions on their sustainability. In this review, we overview specific elements of the biomimetic niche and how recreating such elements can help in vitro propagation of adult stem cells.

Type: Article
Title: Elements of the niche for adult stem cell expansion
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/2041731417725464
Publisher version: http://doi.org/10.1177/2041731417725464
Language: English
Additional information: Copyright © The Author(s) 2017. Creative Commons CC BY: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http:// www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/ open-access-at-sage).
Keywords: Biomimicry, adult stem cells, microenvironment
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1575596
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