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Chronic kidney disease associated cardiovascular disease: scope and limitations of animal models

Sadeghi-Alavijeh, O; Tadayyon, M; Caplin, BD; (2017) Chronic kidney disease associated cardiovascular disease: scope and limitations of animal models. Cardiovascular Endocrinology , 6 (4) pp. 120-127. 10.1097/XCE.0000000000000132. Green open access

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Abstract

Chronic kidney disease (CKD) is a heterogeneous range of disorders affecting up to 11% of the world’s population. The majority of patients with CKD die of cardiovascular disease (CVD) before progressing to end-stage renal disease. CKD patients have an increased risk of atherosclerotic disease as well as a unique cardiovascular phenotype. There remains no clear aetiology for these issues and a better understanding of the pathophysiology of CKD-associated CVD is urgently needed. Although nonanimal studies can provide insights into the nature of disease, the wholeorganism nature of CKD-associated CVD means that highquality animal models, at least for the immediate future, are likely to remain a key tool in improving our understanding in this area. We will discuss the methods used to induce renal impairment in rodents and the methods available to assess cardiovascular phenotype and in each case describe the applicability to humans.

Type: Article
Title: Chronic kidney disease associated cardiovascular disease: scope and limitations of animal models
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/XCE.0000000000000132
Publisher version: http://dx.doi.org/10.1097/XCE.0000000000000132
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1575559
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