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Role of tissue microenvironment resident adipocytes in colon cancer

Tabuso, M; Homer-Vanniasinkam, S; Adya, R; Arasaradnam, RP; (2017) Role of tissue microenvironment resident adipocytes in colon cancer. World Journal of Gastroenterology , 23 (32) pp. 5829-5835. 10.3748/wjg.v23.i32.5829. Green open access

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Abstract

Colorectal cancer (CRC) is a multifactorial disease characterized by several genetic and epigenetic alterations occurring in epithelial cells. It is increasingly recognized that tumour progression is also regulated by tumour microenvironment (TME). The bidirectional cross-talk between tumour resident adipocytes and cancer cells within TME has been proposed as active contributor to carcinogenesis. Tumour resident adipocytes exhibit an activated phenotype characterized by increased secretion of pro-tumorigenic factors (angiogenic/inflammatory/immune) which contribute to cancer cell proliferation, invasion, neoangiogenesis, evasion of immune surveillance and therapy resistance. Furthermore, adipocytes represent a fuel rich source for increasing energy demand of rapidly proliferating tumour cells. Interestingly, a relationship between obesity and molecular variants in CRC has recently been identified. Whether adipose tissue promotes cancer progression in subsets of molecular phenotypes or whether local tissue adipocytes are involved in inactivation of tumour suppressor genes and/or activation of oncogenes still needs to be explored. This editorial highlights the major findings related to cross-talk between adipocytes and colon cancer cells and how local paracrine interactions may promote cancer progression. Furthermore, we provide future strategies in studying colonic TME which could provide insights in bidirectional cross-talk mechanisms between adipocytes and colonic epithelial cells. This could enable to decipher critical signalling pathways of both early colonic carcinogenesis and cancer progression.

Type: Article
Title: Role of tissue microenvironment resident adipocytes in colon cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.3748/wjg.v23.i32.5829
Publisher version: http://doi.org/10.3748/wjg.v23.i32.5829
Language: English
Additional information: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Keywords: Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, Tumour resident adipocytes, Dysfunctional adipocytes, Adipose tissue, Cancer cell-tumour resident adipocyte cross-talk, Colon cancer microenvironment, NF-KAPPA-B, COLORECTAL-CANCER, ADIPOSE-TISSUE, STEM-CELLS, OBESITY, INFLAMMATION, LEPTIN, ANGIOGENESIS, ADIPONECTIN, METASTASIS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1575399
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