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Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

Boto, C; Quartin, E; Cai, Y; Martin-Lorenzo, A; Garcia Cenador, MB; Pinto, S; Gupta, R; ... Ferreira, L; + view all (2017) Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation. Nature Communications , 8 , Article 15204. 10.1038/ncomms15204. Green open access

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Abstract

Leukaemia cells that are resistant to conventional therapies are thought to reside in protective niches. Here, we describe light-inducible polymeric retinoic acid (RA)-containing nanoparticles (NPs) with the capacity to accumulate in the cytoplasm of leukaemia cells for several days and release their RA payloads within a few minutes upon exposure to blue/UV light. Compared to NPs that are not activated by light exposure, these NPs more efficiently reduce the clonogenicity of bone marrow cancer cells from patients with acute myeloid leukaemia (AML) and induce the differentiation of RA-low sensitive leukaemia cells. Importantly, we show that leukaemia cells transfected with light-inducible NPs containing RA can engraft into bone marrow in vivo in the proximity of other leukaemic cells, differentiate upon exposure to blue light and release paracrine factors that modulate nearby cells. The NPs described here offer a promising strategy for controlling distant cell populations and remotely modulating leukaemic niches.

Type: Article
Title: Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/ncomms15204
Publisher version: http://doi.org/10.1038/ncomms15204
Language: English
Additional information: © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, ACUTE PROMYELOCYTIC LEUKEMIA, TRANS-RETINOIC ACID, MYELOID-LEUKEMIA, IN-VIVO, DELIVERY-SYSTEMS, SIRNA DELIVERY, DRUG-DELIVERY, STEM-CELLS, DIFFERENTIATION, THERAPY
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/1575255
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