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Dystonia

De Pablo Fernandez, E; Warner, TT; (2017) Dystonia. British Medical Bulletin , 123 (1) pp. 91-102. 10.1093/bmb/ldx019. Green open access

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Abstract

INTRODUCTION: Dystonia is a clinically heterogeneous group of hyperkinetic movement disorders. Recent advances have provided a better understanding of these conditions with significant clinical impact. SOURCES OF DATA: Peer reviewed journals and reviews. PubMed.gov. AREAS OF AGREEMENT: A recent consensus classification, including the assessment of phenomenology and identification of the dystonia syndromes, has provided a helpful tool for the clinical assessment. New forms of monogenic dystonia have been recently identified. AREAS OF CONTROVERSY: Despite recent advances in the understanding of dystonia, treatment remains symptomatic in most patients. GROWING POINTS: Recent advances in genetics have provided a better understanding of the potential pathogenic mechanisms involved in dystonia. Deep brain stimulation has shown to improve focal and combined forms of dystonia and its indications are constantly expanding. AREAS TIMELY FOR DEVELOPING RESEARCH: Growing understanding of the disease mechanisms involved will allow the development of targeted and disease-modifying therapies in the future.

Type: Article
Title: Dystonia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/bmb/ldx019
Publisher version: http://doi.org/10.1093/bmb/ldx019
Language: English
Additional information: © The Author 2017. Published by Oxford University Press. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Botulinum toxin, dystonia
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/1575188
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