UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Uncovering Capgras delusion using a large-scale medical records database

Bell, V; Marshall, C; Kanji, Z; Wilkinson, S; Halligan, P; Deeley, Q; (2017) Uncovering Capgras delusion using a large-scale medical records database. British Journal of Psychiatry Open , 3 (4) pp. 179-185. 10.1192/bjpo.bp.117.005041. Green open access

[img]
Preview
Text
179.full.pdf - Published version

Download (621kB) | Preview

Abstract

BACKGROUND: Capgras delusion is scientifically important but most commonly reported as single case studies. Studies analysing large clinical records databases focus on common disorders but none have investigated rare syndromes. AIMS: Identify cases of Capgras delusion and associated psychopathology, demographics, cognitive function and neuropathology in light of existing models. METHOD: Combined computational data extraction and qualitative classification using 250 000 case records from South London and Maudsley Clinical Record Interactive Search (CRIS) database. RESULTS: We identified 84 individuals and extracted diagnosis-matched comparison groups. Capgras was not 'monothematic' in the majority of cases. Most cases involved misidentified family members or close partners but others were misidentified in 25% of cases, contrary to dual-route face recognition models. Neuroimaging provided no evidence for predominantly right hemisphere damage. Individuals were ethnically diverse with a range of psychosis spectrum diagnoses. CONCLUSIONS: Capgras is more diverse than current models assume. Identification of rare syndromes complements existing 'big data' approaches in psychiatry. DECLARATION OF INTERESTS: V.B. is supported by a Wellcome Trust Seed Award in Science (200589/Z/16/Z) and the UCLH NIHR Biomedical Research Centre. S.W. is supported by a Wellcome Trust Strategic Award (WT098455MA). Q.D. has received a grant from King's Health Partners.

Type: Article
Title: Uncovering Capgras delusion using a large-scale medical records database
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1192/bjpo.bp.117.005041
Publisher version: https://doi.org/10.1192/bjpo.bp.117.005041
Language: English
Additional information: Copyright © The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license (https://creativecommons.org/licenses/by-nc-nd/4.0/).
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/1574641
Downloads since deposit
100Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item