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Assessing Changes Within the Lumbosacral Spinal Cord in Neurological Disease: Preliminary Results of a Pilot in Vivo MRI Study

Liechti, MD; Yiannakas, M; Budtarad, N; Toosy, AT; Yang, X; Prados Carrasco, F; Miller, DH; ... Panicker, J; + view all (2017) Assessing Changes Within the Lumbosacral Spinal Cord in Neurological Disease: Preliminary Results of a Pilot in Vivo MRI Study. In: The ISMRM 25th Annual Meeting & Exhibition. ISMRM: Honolulu, USA. Green open access

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Abstract

Magnetic resonance imaging (MRI)-derived tissue-specific measures of neuronal loss and demyelination were assessed at the lumbosacral level of the spinal cord (SC) in relation to neurological dysfunction. Acquisition of grey and white matter measures for the lumbosacral SC proved feasible, and were sensitive to detect tissue-specific changes in two neurological disorders commonly associated with lumbosacral cord involvement: Multiple system atrophy and Multiple sclerosis. This preliminary study demonstrates the utility of this cutting edge MRI acquisition method to detect pathological changes in the lumbosacral SC, and is a first step towards establishing new MRI biomarkers for these patient groups.

Type: Proceedings paper
Title: Assessing Changes Within the Lumbosacral Spinal Cord in Neurological Disease: Preliminary Results of a Pilot in Vivo MRI Study
Event: ISMRM 25th Annual Meeting & Exhibition
Location: Honolulu, Hawaii
Dates: 22 April 2017 - 27 April 2017
Open access status: An open access version is available from UCL Discovery
Publisher version: https://www.ismrm.org/2017-annual-meeting-exhibiti...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1574629
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