Liechti, MD;
Yiannakas, M;
Budtarad, N;
Toosy, AT;
Yang, X;
Prados Carrasco, F;
Miller, DH;
... Panicker, J; + view all
(2017)
Assessing Changes Within the Lumbosacral Spinal Cord in Neurological Disease: Preliminary Results of a Pilot in Vivo MRI Study.
In:
The ISMRM 25th Annual Meeting & Exhibition.
ISMRM: Honolulu, USA.
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Abstract
Magnetic resonance imaging (MRI)-derived tissue-specific measures of neuronal loss and demyelination were assessed at the lumbosacral level of the spinal cord (SC) in relation to neurological dysfunction. Acquisition of grey and white matter measures for the lumbosacral SC proved feasible, and were sensitive to detect tissue-specific changes in two neurological disorders commonly associated with lumbosacral cord involvement: Multiple system atrophy and Multiple sclerosis. This preliminary study demonstrates the utility of this cutting edge MRI acquisition method to detect pathological changes in the lumbosacral SC, and is a first step towards establishing new MRI biomarkers for these patient groups.
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