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Remarkable stability of myelinating oligodendrocytes in mice

Tripathi, RB; Jackiewicz, M; McKenzie, IA; Kougioumtzidou, E; Grist, M; Richardson, WD; (2017) Remarkable stability of myelinating oligodendrocytes in mice. Cell Reports , 21 (2) pp. 316-323. 10.1016/j.celrep.2017.09.050. Green open access

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Abstract

New myelin-forming oligodendrocytes (OLs) are generated in the mouse central nervous system during adulthood. These adult-born OLs might augment the existing population, contributing to neural plasticity, or else replace OLs that die in use (turnover). To distinguish between these alternatives, we induced genetic labeling of mature myelinating OLs in young adult mice and tracked their subsequent survival. OL survival rates were region dependent, being higher in corpus callosum (∼90% survival over 20 months) and motor cortex (∼70% survival) than in corticospinal tract or optic nerve (50%–60% survival). Survival rates over the first 8 months were 90%–100% in all regions except the optic nerve. In the corpus callosum, new OLs accumulate during young adulthood and are therefore likely to participate in adaptive myelination. We also found that the number of myelin internodes maintained by individual cortical OLs is stable for at least 8 months but declines ∼12% in the following year.

Type: Article
Title: Remarkable stability of myelinating oligodendrocytes in mice
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.celrep.2017.09.050
Publisher version: http://dx.doi.org/10.1016/j.celrep.2017.09.050
Language: English
Additional information: © 2017 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/1574360
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