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Reconciling the different faces of hippocampal theta: the role of theta oscillations in cognitive, emotional and innate behaviors

Korotkova, T; Ponomarenko, A; Monaghan, C; Poulter, S; Cacucci, F; Wills, TJ; Hasselmo, M; (2018) Reconciling the different faces of hippocampal theta: the role of theta oscillations in cognitive, emotional and innate behaviors. Neuroscience and Biobehavioral Reviews , 85 pp. 65-80. 10.1016/j.neubiorev.2017.09.004. Green open access

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Abstract

The theta oscillation (5–10 Hz) is a prominent behavior-specific brain rhythm. This review summarizes studies showing the multifaceted role of theta rhythm in cognitive functions, including spatial coding, time coding and memory, exploratory locomotion and anxiety-related behaviors. We describe how activity of hippocampal theta rhythm generators − medial septum, nucleus incertus and entorhinal cortex, links theta with specific behaviors. We review evidence for functions of the theta-rhythmic signaling to subcortical targets, including lateral septum. Further, we describe functional associations of theta oscillation properties − phase, frequency and amplitude – with memory, locomotion and anxiety, and outline how manipulations of these features, using optogenetics or pharmacology, affect associative and innate behaviors. We discuss work linking cognition to the slope of the theta frequency to running speed regression, and emotion-sensitivity (anxiolysis) to its y-intercept. Finally, we describe parallel emergence of theta oscillations, theta-mediated neuronal activity and behaviors during development. This review highlights a complex interplay of neuronal circuits and synchronization features, which enables an adaptive regulation of multiple behaviors by theta-rhythmic signaling.

Type: Article
Title: Reconciling the different faces of hippocampal theta: the role of theta oscillations in cognitive, emotional and innate behaviors
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neubiorev.2017.09.004
Publisher version: http://doi.org/10.1016/j.neubiorev.2017.09.004
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Hippocampus; Entorhinal cortex; Memory; Resonance; Grid cells; Place cells; Behaving mice; Anxiety; Speed; Optogenetics
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/1574316
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