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The zebrafish as a promising tool for modeling human brain disorders: A review based upon an IBNS Symposium

Shams, S; Rihel, JM; Ortiz, JG; Gerlai, R; (2018) The zebrafish as a promising tool for modeling human brain disorders: A review based upon an IBNS Symposium. Neuroscience and Biobehavioral Reviews , 85 pp. 176-190. 10.1016/j.neubiorev.2017.09.002. Green open access

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Abstract

The zebrafish represents an excellent compromise between system complexity and practical simplicity, features that make it useful for modeling and mechanistic analysis of complex brain disorders. Also promising are screens for psychoactive drugs with effects on larval and adult zebrafish behavior. This review, based upon a recent symposium held at the 2016 IBNS Congress, provides different perspectives on how the zebrafish may be utilized to advance research into human central nervous system disorders. It starts with a discussion on an important bottleneck in zebrafish research, measuring the behavior of this species (specifically shoaling), and continues with examples on research on autism spectrum disorder in larval zebrafish, on screening natural products for compounds with psychoactive properties in adult zebrafish, and on the development of a zebrafish model of fetal alcohol spectrum disorders. By providing information on a broad spectrum of brain disorders, experimental methods, and scientific approaches using both larval and adult zebrafish, the review is intended to showcase this underutilized laboratory species for behavioral neuroscience and psychopharmacology research.

Type: Article
Title: The zebrafish as a promising tool for modeling human brain disorders: A review based upon an IBNS Symposium
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neubiorev.2017.09.002
Publisher version: http://dx.doi.org/10.1016/j.neubiorev.2017.09.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alcoholism; Anxiety; Autism; Epilepsy; Fetal alcohol spectrum disorders; Psychopharmacology; Social behavior; Zebrafish
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1574312
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