UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

T-shaped Peptide Amphiphiles Self Assemble into Nanofiber Networks

Fisusi, FA; Notman, R; Granger, LA; Malkinson, JP; Schätzlein, AG; Uchegbu, IF; (2017) T-shaped Peptide Amphiphiles Self Assemble into Nanofiber Networks. Pharmaceutical Nanotechnology , 5 (3) pp. 215-219. 10.2174/2211738505666170828095937. Green open access

[img]
Preview
Text
Fisusi_T-shaped_Peptide_Amphiphiles.pdf - Accepted version

Download (1MB) | Preview

Abstract

BACKGROUND: Conventional nanofiber forming peptide amphiphiles comprise a beta sheet forming, short peptide sequence with an alkyl chain attached at one terminus. We report the self-assembly of a peptide amphiphile possessing a mid-chain located alkyl substituent (a T-shaped peptide amphiphile) into nanofiber networks. METHOD: Peptide synthesis was carried out using standard 9-fluorenylmethoxycarbonyl solid phase peptide synthesis protocols, followed by covalent attachment of the alkyl chains to yield target peptide amphiphiles. Self-assembly was then studied using electron microscopy and coarse grained molecular dynamics simulations. RESULTS: T-shaped peptide amphiphiles self-assembled into nanofibers just like linear peptide amphiphiles, but then unlike linear peptide amphiphiles, T-shaped peptide amphiphiles formed inter-fiber associations and ultimately nanofiber networks. CONCLUSION: Changing the position of the alkyl chain in a peptide amphiphile from the terminal end of the peptide to the middle part of the peptide, to form a T-shaped peptide amphiphile, does not disrupt the molecular interactions required for the self-assembly of the peptide amphiphiles into nanofibers.

Type: Article
Title: T-shaped Peptide Amphiphiles Self Assemble into Nanofiber Networks
Location: United Arab Emirates
Open access status: An open access version is available from UCL Discovery
DOI: 10.2174/2211738505666170828095937
Publisher version: https://doi.org/10.2174/2211738505666170828095937
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Peptide amphiphiles, beta sheet, drug delivery., molecular dynamics simulations, nanofibers, networks, peptide synthesis, self-assemblies
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/1573975
Downloads since deposit
84Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item