UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium

Minlikeeva, AN; Freudenheim, JL; Eng, KH; Cannioto, RA; Friel, G; Szender, JB; Segal, B; ... Moysich, KB; + view all (2017) History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium. Cancer Epidemiology Biomarkers & Prevention , 26 (9) pp. 1470-1473. 10.1158/1055-9965.EPI-17-0367. Green open access

[thumbnail of Gentry-Maharaj_Cancer Epidemiol Biomarkers Prev.pdf]
Preview
Text
Gentry-Maharaj_Cancer Epidemiol Biomarkers Prev.pdf - Accepted Version

Download (281kB) | Preview

Abstract

Background: Comorbidities can affect survival of ovarian cancer patients by influencing treatment efficacy. However, little evidence exists on the association between individual concurrent comorbidities and prognosis in ovarian cancer patients. Methods: Among patients diagnosed with invasive ovarian carcinoma who participated in 23 studies included in the Ovarian Cancer Association Consortium, we explored associations between histories of endometriosis, asthma, depression, osteoporosis, and autoimmune, gallbladder, kidney, liver and neurological diseases and overall and progression-free survival. Using Cox proportional hazards regression models adjusted for age at diagnosis, stage of disease, histology, and study site, we estimated pooled hazard ratios and 95% confidence intervals to assess associations between each comorbidity and ovarian cancer outcomes. Results: None of the comorbidities were associated with ovarian cancer outcome in the overall sample nor in strata defined by histological subtype, weight status, age at diagnosis or stage of disease (local/regional vs. advanced). Conclusions: Histories of endometriosis, asthma, depression, osteoporosis, and autoimmune, gallbladder, kidney, liver, or neurologic diseases were not associated with ovarian cancer overall or progression-free survival. Impact: These previously diagnosed chronic diseases do not appear to affect ovarian cancer prognosis

Type: Article
Title: History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium
Open access status: An open access version is available from UCL Discovery
DOI: 10.1158/1055-9965.EPI-17-0367
Publisher version: http://doi.org/10.1158/1055-9965.EPI-17-0367
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1573924
Downloads since deposit
72Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item