Jenkins, D;
(2016)
Hedgehog Signaling in Development and Disease.
In: Bradshaw, R and Stahl, P, (eds.)
Encyclopedia of Cell Biology.
(pp. 76-85).
Elsevier: London, UK.
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Jenkins Jenkins 06_08_14.pdf
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Abstract
Hedgehog (HH) signaling is crucial for normal development and tissue homeostasis, and mutations affecting the pathway have been described in congenital malformations and cancers. Key steps in the pathway include ligand production and binding to its receptor, followed by the processing of the GLI transcription factors which feed into gene regulatory networks. Secreted over many cell diameters in some locations, HH ligands are classic morphogens, patterning tissues such as the neural tube and limb bud. Many small molecules have been shown to target the HH pathway, offering hope for the treatment of HH-associated disease.
| Type: |
Book chapter
|
| Title: |
Hedgehog Signaling in Development and Disease |
| ISBN-13: |
9780123947963 |
| DOI: |
10.1016/B978-0-12-394447-4.30007-4 |
| Publisher version: |
https://doi.org/10.1016/B978-0-12-394447-4.30007-4 |
| Language: |
English |
| Additional information: |
This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: |
Acrocapitofemoral dysplasia, Basal cell carcinoma, Cyclopamine, Glioma-associated transcription factors, Greig cephalopolysyndactyly syndrome, Hedgehog signaling, Holoprosencephaly, Intraflagellar transport, Medulloblastoma, Patched, Polydactyly, Primary cilia, Smoothened |
| UCL classification: |
UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept |
| URI: |
https://discovery.ucl.ac.uk/id/eprint/1573661 |
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