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Investigating Dementia via a multicompartmental poroelastic model of parenchymal tissue

Guo, L; Vardakis, IC; Lassila, T; Mitolo, M; Ravikumar, N; Chou, D; Lange, M; ... Ventikos, Y; + view all (2017) Investigating Dementia via a multicompartmental poroelastic model of parenchymal tissue. In: Nithiarasu, P and Robertson, AM, (eds.) Proceedings of the 5th International Conference on Computational & Mathematical Biomedical Engineering (CMBE 2017), Volume 1. (pp. pp. 371-374). Zeta Computational Resources Ltd: Swansea, UK. Green open access

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Abstract

In this paper, a workflow within the VPH-DARE@IT Clinical Research Platform is presented. This is used to model the biomechanical behaviour of perfused brain tissue. This workflow features a 3D multicompartmental poroelastic framework, patient-specific brain anatomy representations and continuous waveforms of internal carotid and vertebral arteries, which are used as a means of personalizing the boundary conditions that feed the arterial compartment of the in-house poroelastic solver. Results are shown comparing CSF/ISF clearance and accumulation in two males of similar age, both are non-smokers, however one is more active and is diagnosed with MCI and experiences less sleep.

Type: Proceedings paper
Title: Investigating Dementia via a multicompartmental poroelastic model of parenchymal tissue
Event: CMBE17: 5th International Conference on Computational & Mathematical Biomedical Engineering, 10 - 12 April 2017, Pittsburgh, USA
Location: Pittsburgh, USA
Dates: 10 April 2017 - 12 April 2017
ISBN-13: 9780956291448
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.compbiomed.net/2017/cmbe-proceedings.ht...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Dementia, Poroelasticity, Periventricular Lucency, FEM
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1573540
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