UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Hospital admission for hyperemesis gravidarum in women at increased risk of spontaneous preterm birth

Kleine, I; Da Silva, A; Ahmed, W; Forya, F; Whitten, SM; David, AL; James, CP; (2017) Hospital admission for hyperemesis gravidarum in women at increased risk of spontaneous preterm birth. Birth , 44 (4) pp. 384-389. 10.1111/birt.12303. Green open access

[img]
Preview
Text
Hospital admission for hyperemesis gravidarum in women at increased risk of spontaneous preterm birth.pdf - Published version

Download (442kB) | Preview

Abstract

BACKGROUND: Progesterone administration prevents spontaneous preterm birth (sPTB) in women at increased risk. Progesterone concentration is lower in women with subsequent sPTB. Conversely, high concentrations of progesterone are implicated in the pathogenesis of hyperemesis gravidarum (HG). We hypothesized that women at increased risk of sPTB or spontaneous late miscarriage would be less likely to have a diagnosis of HG. To explore this hypothesis, we compared the incidence of HG in women at increased risk of sPTB and women with no identifiable risk factors. METHODS: Women at increased risk of sPTB were identified from a specialist Preterm Birth Clinic (PTBC) database where criteria for PTBC attendance are previous cervical surgery, previous sPTB <34 weeks, previous spontaneous late miscarriage, incidental sonographic cervical shortening, and uterine anomaly. Hospital antenatal booking and coding records for the same time period were examined to identify HG admissions. Women with multiple gestations, trophoblastic disease, or pre-existing abnormal thyroid function were excluded. The incidence of HG among PTBC (n=394) and non-PTBC attendees (n=4762) was calculated. RESULTS: The incidence of HG was lower in women at increased risk of sPTB (1.52%, n=6) compared with women with no identifiable risk factor for sPTB (3.33%, n=159; P=.049). CONCLUSION: Hospital admission for HG is reduced in women with risk factors for sPTB compared with those without risk factors. Exploration of the pathogenesis of HG may improve understanding of the mechanisms underlying sPTB.

Type: Article
Title: Hospital admission for hyperemesis gravidarum in women at increased risk of spontaneous preterm birth
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/birt.12303
Publisher version: https://doi.org/10.1111/birt.12303
Language: English
Additional information: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Copyright © 2017 the Authors. Birth published by Wiley Periodicals, Inc.
Keywords: Early pregnancy admissions, hyperemesis gravidarum, preterm birth
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1573153
Downloads since deposit
52Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item