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The architecture of transcription elongation

Fouqueau, T; Werner, F; (2017) The architecture of transcription elongation. Science , 357 (6354) pp. 871-872. 10.1126/science.aao4754. Green open access

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Abstract

The molecular machines that carry out transcription in all domains of life—bacteria, archaea, and eukaryotes—are multisubunit RNA polymerases (1). Over the past 15 years, structural analyses at ever higher resolution, in particular hybrid approaches that combine x-ray crystallography and single-particle cryo–electron microscopy, have provided detailed insights into how these enzymes work (2). On page 921 of this issue, Ehara et al. (3) apply such a multidisciplinary structural approach and in vitro transcription assays to reveal functional insights into a complete elongation complex from the yeast Komagataella pastoris, encompassing RNA polymerase II (RNAPII) and the transcription elongation factors Elf1, Spt4/5, and TFIIS. The results uncover the detailed molecular mechanisms by which these factors can not only enhance transcription elongation, but also pausing.

Type: Article
Title: The architecture of transcription elongation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/science.aao4754
Publisher version: http://doi.org/10.1126/science.aao4754
Language: English
Additional information: Copyright © 2017, American Association for the Advancement of Science http://www.sciencemag.org/about/science-licenses-journal-article-reuse. This is an article distributed under the terms of the Science Journals Default License. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, RNA-POLYMERASE CLAMP, 3 DOMAINS, INITIATION, COMPLEX, LIFE, TFE
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1573121
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