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Multimodal characterization of gray matter alterations in neuromyelitis optica

Liu, Yaou; Jiang, Xueyan; Butzkueven, Helmut; Duan, Yunyun; Huang, Jing; Ren, Zhuoqiong; Dong, Huiqing; ... Wang, Jinhui; + view all (2018) Multimodal characterization of gray matter alterations in neuromyelitis optica. Multiple Sclerosis Journal , 24 (10) 1308 -1316. 10.1177/1352458517721053. Green open access

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Abstract

OBJECTIVE: To investigate structural and functional alterations of gray matter (GM) and examine their clinical relevance in neuromyelitis optica (NMO) using multimodal magnetic resonance imaging (MRI) techniques. METHODS: A total of 35 NMO and 36 healthy controls (HC) were recruited in this study. Cortical lesions were investigated by double inversion recovery technique. Five voxel-wise MRI measurements were obtained for each participant in the GM including gray matter volume (GMV), fractional anisotropy (FA), mean diffusivity (MD), amplitude of low-frequency fluctuation (ALFF), and weighted functional connectivity strength (wFCS). Between-group differences, cross-modality relationships, and MRI-clinical correlations were examined. RESULTS: No cortical lesions were found in NMO. Compared to HC, NMO patients exhibited significantly decreased GMV in deep GM and cortical regions involving visual function and cognition. Diffusion GM abnormalities were widespread in the patients. Decreased ALFF and wFCS were observed in the patients in sensorimotor, visual, cognition, and cerebellar sites. GM structural alterations were correlated with cognitive but not physical disability scores of the patients. CONCLUSION: Despite the lack of focal cortical lesions, patients with NMO exhibit both structural and functional alterations of GM in cerebrum and cerebellum that predominantly involve deep GM, visual, motor, and cognitive regions. GM alterations are associated with cognitive impairment but not physical disability.

Type: Article
Title: Multimodal characterization of gray matter alterations in neuromyelitis optica
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1352458517721053
Publisher version: http://doi.org/10.1177/1352458517721053
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Neuromyelitis optica, diffusion tensor imaging, gray matter, resting-state functional MRI, structural MRI
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/1573024
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