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Stem/progenitor cells in pituitary organ homeostasis and tumourigenesis

Haston, S; Manshaei, S; Martinez-Barbera, JP; (2018) Stem/progenitor cells in pituitary organ homeostasis and tumourigenesis. Journal of Endocrinology , 236 (1) R1-R13. 10.1530/JOE-17-0258. Green open access

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Abstract

Evidence for the presence of pituitary gland stem cells has been provided over the last decade using a combination of approaches including in vitro clonogenicity assays, flow cytometric side population analysis, immunohistochemical analysis and genetic approaches. These cells have been demonstrated to be able to self-renew and undergo multipotent differentiation to give rise to all hormonal lineages of the anterior pituitary. Furthermore, evidence exists for their contribution to regeneration of the organ and plastic responses to changing physiological demand. Recently, stem-like cells have been isolated from pituitary neoplasms raising the possibility that a cytological hierarchy exists, in keeping with the cancer stem cell paradigm. In this manuscript, we review the evidence for the existence of pituitary stem cells, their role in maintaining organ homeostasis and the regulation of their differentiation. Furthermore, we explore the emerging concept of stem cells in pituitary tumours and their potential roles in these diseases.

Type: Article
Title: Stem/progenitor cells in pituitary organ homeostasis and tumourigenesis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1530/JOE-17-0258
Publisher version: http://dx.doi.org/10.1530/JOE-17-0258
Additional information: © 2018 The authors. This work is licensed under a Creative Commons Attribution 3.0 Unported License.
Keywords: adamantinomatous craniopharyngioma, homeostasis, pituitary, pituitary adenoma, stem cell, Animals, Cell Transformation, Neoplastic, Gene Expression, Homeostasis, Humans, Neoplastic Stem Cells, Pituitary Gland, Pituitary Hormones, Pituitary Neoplasms, Stem Cells
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1572796
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