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Prostate lesion detection and localization based on locality alignment discriminant analysis

Lin, M; Chen, W; Zhao, M; Gibson, E; Bastian-Jordan, M; Cool, DW; Kassam, Z; ... Chiu, B; + view all (2017) Prostate lesion detection and localization based on locality alignment discriminant analysis. In: Armato, SG and Petrick, NA, (eds.) Proceedings Volume 10134, Medical Imaging 2017: Computer-Aided Diagnosis. SPIE: Florida, United States. Green open access

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Abstract

Prostatic adenocarcinoma is one of the most commonly occurring cancers among men in the world, and it also the most curable cancer when it is detected early. Multiparametric MRI (mpMRI) combines anatomic and functional prostate imaging techniques, which have been shown to produce high sensitivity and specificity in cancer localization, which is important in planning biopsies and focal therapies. However, in previous investigations, lesion localization was achieved mainly by manual segmentation, which is time-consuming and prone to observer variability. Here, we developed an algorithm based on locality alignment discriminant analysis (LADA) technique, which can be considered as a version of linear discriminant analysis (LDA) localized to patches in the feature space. Sensitivity, specificity and accuracy generated by the proposed algorithm in five prostates by LADA were 52.2%, 89.1% and 85.1% respectively, compared to 31.3%, 85.3% and 80.9% generated by LDA. The delineation accuracy attainable by this tool has a potential in increasing the cancer detection rate in biopsies and in minimizing collateral damage of surrounding tissues in focal therapies.

Type: Proceedings paper
Title: Prostate lesion detection and localization based on locality alignment discriminant analysis
Event: Conference on Medical Imaging - Computer-Aided Diagnosis
Location: Orlando, FL
Dates: 13 February 2017 - 16 February 2017
ISBN-13: 978-1-5106-0713-2
Open access status: An open access version is available from UCL Discovery
DOI: 10.1117/12.2255621
Publisher version: https://doi.org/10.1117/12.2255621
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Prostate cancer, Multiparametric MRI (mpMRI), Lesion localization, Locality alignment discriminant analysis (LADA)
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1571879
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