Herceg, Z;
Ghantous, A;
Wild, CP;
Sklias, A;
Casati, L;
Duthie, SJ;
Fry, R;
... Hernandez-Vargas, H; + view all
(2017)
Roadmap for Investigating Epigenome Deregulation and Environmental Origins of Cancer.
International Journal of Cancer
10.1002/ijc.31014.
(In press).
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Abstract
The interaction between the (epi)genetic makeup of an individual and his/her environmental exposure record (exposome) is accepted as a determinant factor for a significant proportion of human malignancies. Recent evidence has highlighted the key role of epigenetic mechanisms in mediating gene-environment interactions and translating exposures into tumorigenesis. There is also growing evidence that epigenetic changes may be risk factor-specific ("fingerprints") that should prove instrumental in the discovery of new biomarkers in cancer. Here, we review the state of the science of epigenetics associated with environmental stimuli and cancer risk, highlighting key developments in the field. Critical knowledge gaps and research needs are discussed as well as advances in epigenomics that may help an understanding of the functional relevance of epigenetic alterations. Key elements required for causality inferences linking epigenetic changes to exposure and cancer are discussed as well as how these alterations can be incorporated in carcinogen evaluation and in understanding mechanisms underlying epigenome deregulation by the environment.
| Type: | Article |
|---|---|
| Title: | Roadmap for Investigating Epigenome Deregulation and Environmental Origins of Cancer |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/ijc.31014 |
| Publisher version: | http://dx.doi.org/10.1002/ijc.31014 |
| Language: | English |
| Additional information: | Copyright © 2017 International Agency for Research on Cancer (IARC/WHO); licensed by UICC. This is an open access article distributed under the terms of the Creative Commons Attribution IGO License. IARC's preferred IGO license is the non-commercial: https://creativecommons.org/licenses/by-nc/3.0/igo/legalcode which permits non-commercial unrestricted use, distribution and reproduction in any medium, provided that the original work is properly cited. In any reproduction of this article there should not be any suggestion that IARC/WHO or the article endorse any specific organization or products. The use of the IARC/WHO logo is not permitted. This notice should be preserved along with the article's URL. |
| Keywords: | epigenetics; environment; cancer; molecular mechanisms; research gaps; perspectives; biomarkers |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1571620 |
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