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The role of trimethylamine N-oxide as a mediator of cardiovascular complications in chronic kidney disease

Tomlinson, JAP; Wheeler, DC; (2017) The role of trimethylamine N-oxide as a mediator of cardiovascular complications in chronic kidney disease. Kidney International , 92 (4) pp. 809-815. 10.1016/j.kint.2017.03.053. Green open access

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Abstract

Patients with chronic kidney disease (CKD) have an enhanced risk of cardiovascular (CV) morbidity and mortality when compared with age- and gender-matched individuals with normal kidney function. Trimethlyamine N-oxide (TMAO) is a gut-derived amine oxide that has been implicated in the causation of CV diseases. Plasma TMAO is cleared by the kidney, and TMAO levels are elevated in CKD. Experimental studies have identified pathogenic mechanisms by which TMAO may contribute to CV disease through dysregulation of lipid metabolism, enhanced macrophage foam cell formation, and platelet dysfunction. Safe and well-tolerated therapeutic interventions such as pre- and probiotics, which modify the gut microbiome, offer the opportunity for interventional studies. This review examines the pathogenicity of TMAO, its value as a biomarker, and its potential as a therapeutic target in the context of CKD.

Type: Article
Title: The role of trimethylamine N-oxide as a mediator of cardiovascular complications in chronic kidney disease
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.kint.2017.03.053
Publisher version: http://doi.org/10.1016/j.kint.2017.03.053
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cardiovascular disease, chronic kidney disease, microbiome
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1571587
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