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TRIM21 and the Function of Antibodies inside Cells

Rhodes, DA; Isenberg, DA; (2017) TRIM21 and the Function of Antibodies inside Cells. Trends in Immunology , 38 (12) pp. 916-926. 10.1016/j.it.2017.07.005. Green open access

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Abstract

Therapeutic antibodies targeting disease-associated antigens are key tools in the treatment of cancer and autoimmunity. So far, therapeutic antibodies have targeted antigens that are, or are presumed to be, extracellular. A largely overlooked property of antibodies is their functional activity inside cells. The diverse literature dealing with intracellular antibodies emerged historically from studies of the properties of some autoantibodies. The identification of tripartite motif (TRIM) 21 as an intracellular Fc receptor linking cytosolic antibody recognition to the ubiquitin proteasome system brings this research into sharper focus. We review critically the research related to intracellular antibodies, link this to the TRIM21 effector mechanism, and highlight how this work is exposing the previously restricted intracellular space to the potential of therapeutic antibodies.

Type: Article
Title: TRIM21 and the Function of Antibodies inside Cells
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.it.2017.07.005
Publisher version: https://doi.org/10.1016/j.it.2017.07.005
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Immunology, ANTI-DNA ANTIBODIES, FC-RECEPTOR TRIM21, INTRACELLULAR ANTIBODY, LIVING CELLS, IN-VIVO, MAMMALIAN-CELLS, THERAPEUTIC IMPLICATIONS, LUPUS AUTOANTIBODIES, CELLULAR DYSFUNCTION, NUCLEAR-LOCALIZATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1571516
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