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Field repetition and local mapping in the hippocampus and medial entorhinal cortex

Grieves, RM; Duvelle, É; Wood, ER; Dudchenko, PA; (2017) Field repetition and local mapping in the hippocampus and medial entorhinal cortex. Journal of Neurophysiology , 118 (4) pp. 2378-2388. 10.1152/jn.00933.2016. Green open access

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Abstract

Hippocampal place cells support spatial cognition and are thought to form the neural substrate of a global 'cognitive map'. A widely held view is that parts of the hippocampus also underlie the ability to separate patterns, or to provide different neural codes for distinct environments. However, a number of studies have shown that in environments composed of multiple, repeating compartments, place cells and other spatially modulated neurons show the same activity in each local area. This repetition of firing fields may reflect pattern completion, and may make it difficult for animals to distinguish similar local environments. In this review we will (a) highlight some of the navigation difficulties encountered by humans in repetitive environments, (b) summarise literature demonstrating that place and grid cells represent local and not global space, and (c) attempt to explain the origin of these phenomena. We argue that the repetition of firing fields can be a useful tool for understanding of the relationship between grid cells in the entorhinal cortex and place cells in the hippocampus, the spatial inputs shared by these cells, and the propagation of spatially-related signals through these structures.

Type: Article
Title: Field repetition and local mapping in the hippocampus and medial entorhinal cortex
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1152/jn.00933.2016
Publisher version: http://doi.org/10.1152/jn.00933.2016
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Field repetition, fragmentation, grid cell, place cell, spatial cognition
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/1571510
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