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Optimizing Research to Speed Up Availability of Pediatric Antiretroviral Drugs and Formulations

Penazzato, M; Gnanashanmugam, D; Rojo, P; Lallemant, M; Lewis, LL; Rocchi, F; Saint Raymond, A; ... Abrams, EJ; + view all (2017) Optimizing Research to Speed Up Availability of Pediatric Antiretroviral Drugs and Formulations. Clinical Infectious Diseases , 64 (11) pp. 1597-1603. 10.1093/cid/cix194. Green open access

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Abstract

Globally 1.8 million children are living with human immunodeficiency virus (HIV), yet only 51% of those eligible actually start treatment. Research and development (R&D) for pediatric antiretrovirals (ARVs) is a lengthy process and lags considerably behind drug development in adults. Providing safe, effective, and well-tolerated drugs for children remains critical to ensuring scale-up globally. We review current approaches to R&D for pediatric ARVs and suggest innovations to enable simplified, faster, and more comprehensive strategies to develop optimal formulations. Several approaches could be adopted, including focusing on a limited number of prioritized formulations and strengthening existing partnerships to ensure that pediatric investigation plans are developed early in the drug development process. Simplified and more efficient mechanisms to undertake R&D need to be put in place, and financing mechanisms must be made more sustainable. Lessons learned from HIV should be shared to support progress in developing pediatric formulations for other diseases, including tuberculosis and viral hepatitis.

Type: Article
Title: Optimizing Research to Speed Up Availability of Pediatric Antiretroviral Drugs and Formulations
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/cid/cix194
Publisher version: https://doi.org/10.1093/cid/cix194
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: antiretrovirals, children, formulations, HIV, research
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1571459
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