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Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing

Foukas, LC; Bettedi, L; (2017) Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing. Biogerontology 10.1007/s10522-017-9724-6. (In press). Green open access

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Abstract

The field of the biology of ageing has received increasing attention from a biomedical point of view over the past decades. The main reason has been the realisation that increases in human population life expectancy are accompanied by late onset diseases. Indeed, ageing is the most important risk factor for a number of neoplastic, neurodegenerative and metabolic pathologies. Advances in the knowledge of the genetics of ageing, mainly through research in model organisms, have implicated various cellular processes and the respective signalling pathways that regulate them in cellular and organismal ageing. Associated with ageing is a dysregulation of metabolic homeostasis usually manifested as age-related obesity, diminished insulin sensitivity and impaired glucose and lipid homeostasis. Metabolic deterioration contributes to the ageing phenotype and metabolic pathologies are thought to be one of the main factors limiting the potential for lifespan extension. Great efforts have been directed towards identifying pharmacological interventions with the potential to improve healthspan and a number of natural and synthetic compounds have shown promise in achieving beneficial metabolic effects.

Type: Article
Title: Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s10522-017-9724-6
Publisher version: https://doi.org/10.1007/s10522-017-9724-6
Language: English
Additional information: © The Author(s) 2017. This article is an open access publication
Keywords: Ageing, PI3K, Insulin resistance, Metabolism, Obesity, Diabetes
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/1570447
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