UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Actively controlled release of Dexamethasone from neural microelectrodes in a chronic in vivo study

Boehler, C; Kleber, C; Martini, N; Xie, Y; Dryg, I; Stieglitz, T; Hofmann, UG; (2017) Actively controlled release of Dexamethasone from neural microelectrodes in a chronic in vivo study. Biomaterials , 129 pp. 176-187. 10.1016/j.biomaterials.2017.03.019. Green open access

[thumbnail of 1-s2.0-S014296121730162X-main.pdf]
Preview
Text
1-s2.0-S014296121730162X-main.pdf - Published Version

Download (2MB) | Preview

Abstract

Stable interconnection to neurons in vivo over long time-periods is critical for the success of future advanced neuroelectronic applications. The inevitable foreign body reaction towards implanted materials challenges the stability and an active intervention strategy would be desirable to treat inflammation locally. Here, we investigate whether controlled release of the anti-inflammatory drug Dexamethasone from flexible neural microelectrodes in the rat hippocampus has an impact on probe-tissue integration over 12 weeks of implantation. The drug was stored in a conducting polymer coating (PEDOT/Dex), selectively deposited on the electrode sites of neural probes, and released on weekly basis by applying a cyclic voltammetry signal in three electrode configuration in fully awake animals. Dex-functionalized probes provided stable recordings and impedance characteristics over the entire chronic study. Histological evaluation after 12 weeks of implantation revealed an overall low degree of inflammation around all flexible probes whereas electrodes exposed to active drug release protocols did have neurons closer to the electrode sites compared to controls. The combination of flexible probe technology with anti-inflammatory coatings accordingly offers a promising approach for enabling long-term stable neural interfaces.

Type: Article
Title: Actively controlled release of Dexamethasone from neural microelectrodes in a chronic in vivo study
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.biomaterials.2017.03.019
Publisher version: http://doi.org/10.1016/j.biomaterials.2017.03.019
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Anti-inflammatory coating, Controlled drug release, Flexible neural implant, Foreign body reaction, Polyimide multisite micro-electrode
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1570370
Downloads since deposit
151Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item