Goh, CF;
Moffat, JG;
Craig, DQM;
Hadgraft, J;
Lane, ME;
(2017)
Nano-thermal imaging of the stratum corneum and its potential use for understanding of the mechanism of skin penetration enhancer.
Thermochimica Acta
, 655
pp. 278-283.
10.1016/j.tca.2017.07.013.
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Abstract
Nano-thermal analysis (nano-TA) is a localised thermal technique which maps a surface in terms of thermal transitions by combining atomic force microscopy with the use of thermal probes, allowing a spatial resolution of sub–100 nm. In this communication, we describe the application of a localised nano-TA approach, transition temperature microscopy (TTM), to investigate the thermotropic properties of porcine stratum corneum (PSC) as a function of depth and the influence of penetration enhancer on the nano-thermal properties of PSC. The investigations were conducted on PSC removed using tape strips. The transition temperature of PSC recorded at ∼220 °C was ascribed to protein denaturation/degradation. A decrease in the transition temperature was observed with an increase of skin depth. ‘Transition depression’ was observed when PSC was treated with propylene glycol, suggesting its water extraction effect on SC protein and a drop in the biomechanical properties of the SC. TTM has the potential to be extended to on in situ investigations of various penetration enhancers.
| Type: | Article |
|---|---|
| Title: | Nano-thermal imaging of the stratum corneum and its potential use for understanding of the mechanism of skin penetration enhancer |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tca.2017.07.013 |
| Publisher version: | http://doi.org/10.1016/j.tca.2017.07.013 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Nano-TA, Stratum corneum, Protein denaturation/degradation, Porcine skin, Skin penetration enhancer |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1570193 |
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