Nicholson, L; Sivapathasuntharam, C; Zola, M; Hykin, P; Bainbridge, JW; Sivaprasad, S; (2017) Retinal Oximetry Differences Between Optic Disc Collateral Vessels and New Vessels. [Letter]. JAMA Ophthalmology , 135 (9) pp. 1003-1004. 10.1001/jamaophthalmol.2017.2624.

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Abstract

Collateral vessels and new vessels are 2 distinct processes that occur on the optic disc in retinal vascular disorders. Morphological differences between these 2 phenomena have been described previously using multiple imaging modalities. Studies using invasive methods have reported increased preretinal oxygen tension in eyes with new vessels. However, to our knowledge, noninvasive oximetry measurements of disc collateral vessels or new vessels have not been reported to-date. A noninvasive method of quantifying and differentiating these 2 processes will add value in understanding the mechanisms of the consequences of retinal vascular diseases. We hypothesized that blood in disc collateral vessels in venous occlusion should have a lower oxygen saturation compared with blood in disc new vessels given that collateral vessels develop to bypass an obstruction in the venous circulation unlike the development of new vessels, which is a proliferative process driven by hypoxia.

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