Foin, N;
Lu, S;
Ng, J;
Bulluck, H;
Hausenloy, DJ;
Wong, PE;
Virmani, R;
(2017)
Stent malapposition and the risk of stent thrombosis: mechanistic insights from an in vitro model.
EuroIntervention
, 13
(9)
10.4244/EIJ-D-17-00381.
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Abstract
AIMS: To examine the effect of under-expansion on stent thrombogenicity with an in-vitro perfusion model. METHOD AND RESULTS: Drug eluting stent (DES) samples were partially under-deployed in silicone tubes and perfused with porcine blood containing 10% Anticoagulant Citrate Dextrose solution for 4 minutes at a flow rate of 200ml/min. Thrombus formation was evaluated and compared between the well apposed and malapposed sections. The malapposed sections showed significantly more thrombus formation compared to the well apposed sections (13.9 vs 0.41 mm2, p<0.001). CONCLUSIONS: Stent malapposition has a very direct impact on thrombus formation. Optimized stent implantation is required to minimize malapposition in DES and BVS to reduce thrombus formation.
| Type: | Article |
|---|---|
| Title: | Stent malapposition and the risk of stent thrombosis: mechanistic insights from an in vitro model |
| Location: | France |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.4244/EIJ-D-17-00381 |
| Publisher version: | http://doi.org/10.4244/EIJ-D-17-00381 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Incomplete Apposition, Stent thrombosis, Malapposition, Hemodynamics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1570095 |
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