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Mapping Myocardial Salvage Index by Extracellular Volume Fraction Are We There Yet?

Bulluck, H; Hausenloy, DJ; (2017) Mapping Myocardial Salvage Index by Extracellular Volume Fraction Are We There Yet? [Editorial comment]. Circulation: Cardiovascular Imaging , 10 (7) , Article e006680. 10.1161/CIRCIMAGING.117.006680. Green open access

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Abstract

In ST-segment–elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention (PPCI), the myocardial salvage index (MSI) provides a more sensitive measure for assessing the efficacy of novel cardioprotective therapies, than an absolute reduction in myocardial infarct (MI) size. Knowledge of the MI size and the size of the area at risk (AAR) are prerequisites for measuring the MSI, and both may be obtained by cardiovascular magnetic resonance (CMR) in reperfused STEMI patients, with the MSI shown to predict clinical outcomes after PPCI.1 CMR is considered the gold standard imaging modality for quantifying MI size, and it can also delineate the edema-based AAR, with T2- and T1-mapping CMR emerging as the most robust techniques,2 although no consensus has yet been reached.

Type: Article
Title: Mapping Myocardial Salvage Index by Extracellular Volume Fraction Are We There Yet?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1161/CIRCIMAGING.117.006680
Publisher version: http://doi.org/10.1161/CIRCIMAGING.117.006680
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/1570094
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