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Zinc and Strontium based Phosphate glass beads: a novel material for bone tissue engineering

Alqaysi, M; Aldaadaa, A; Mordan, N; Shah, R; Knowles, JC; (2017) Zinc and Strontium based Phosphate glass beads: a novel material for bone tissue engineering. Biomedical Materials , 12 , Article 065011. 10.1088/1748-605X/aa8346. Green open access

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Abstract

Degradable phosphate-based glasses that contain strontium, zinc and calcium were investigated to examine its function as an osteoconductive material. Glass beads of the general formula of (P2O5)-(Na2O)-(TiO2)-(CaO)-(SrO) or (ZnO) were prepared by melt quench technique followed by milling and spheroidisation. Glass bead size distribution was initially measured by SEM. Then, some of these samples were immersed in deionized water to evaluate both the surface changes and measure the ion release rate, whereas other glass beads samples were incubated in culture media to determine pH changes. Furthermore, human osteoblast-like osteosarcoma cells MG-63 and human mesenchymal stem cells were seeded on the glass beads to determine its cytocompatibility via applying CCK assay, ALP assay and Ca assay. SEM images and fluorescence images of confocal microscopy were performed for the cellular studies. While mass degradation and ion release results displayed a significant increase with zinc and strontium incorporation within time, pH results showed an initial increase in pH followed by a decrease. Cellular studies emphasised that all formulations enhanced cellular proliferation. More specifically, ZnO5 and SrO17.5 displayed more promising results although they were insignificantly different from that of control (p>0.05). This may suggest their applicability in hard tissue engineering.

Type: Article
Title: Zinc and Strontium based Phosphate glass beads: a novel material for bone tissue engineering
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/1748-605X/aa8346
Publisher version: http://dx.doi.org/10.1088/1748-605X/aa8346
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Phosphate based glass, biocompatibility, osteogenetic differentiation, strontium, tissue engineering, zinc
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1569663
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