Alqaysi, M; Aldaadaa, A; Mordan, N; Shah, R; Knowles, JC; (2017) Zinc and Strontium based Phosphate glass beads: a novel material for bone tissue engineering. Biomedical Materials , 12 , Article 065011. 10.1088/1748-605X/aa8346.

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Text Zinc and Strontium Based Phosphate Glass Beads A Material for Bone Tissue Engineering (R2).pdf - Accepted Version Download (4MB) | Preview

Abstract

Degradable phosphate-based glasses that contain strontium, zinc and calcium were investigated to examine its function as an osteoconductive material. Glass beads of the general formula of (P2O5)-(Na2O)-(TiO2)-(CaO)-(SrO) or (ZnO) were prepared by melt quench technique followed by milling and spheroidisation. Glass bead size distribution was initially measured by SEM. Then, some of these samples were immersed in deionized water to evaluate both the surface changes and measure the ion release rate, whereas other glass beads samples were incubated in culture media to determine pH changes. Furthermore, human osteoblast-like osteosarcoma cells MG-63 and human mesenchymal stem cells were seeded on the glass beads to determine its cytocompatibility via applying CCK assay, ALP assay and Ca assay. SEM images and fluorescence images of confocal microscopy were performed for the cellular studies. While mass degradation and ion release results displayed a significant increase with zinc and strontium incorporation within time, pH results showed an initial increase in pH followed by a decrease. Cellular studies emphasised that all formulations enhanced cellular proliferation. More specifically, ZnO5 and SrO17.5 displayed more promising results although they were insignificantly different from that of control (p>0.05). This may suggest their applicability in hard tissue engineering.

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