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Fowler's syndrome: a primary disorder of urethral sphincter relaxation

Panicker, JN; Pakzad, M; Fowler, CJ; (2018) Fowler's syndrome: a primary disorder of urethral sphincter relaxation. The Obstetrician and Gynaecologist , 20 (2) pp. 95-100. 10.1111/tog.12448. Green open access

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Abstract

Key content: Urinary retention is a relatively uncommon presentation in young women. Women with Fowler's syndrome are often found to have an abnormally elevated urethral pressure profile, increased urethral sphincter volume and characteristically abnormal electromyography of the urethral sphincter. The only treatment that has been found to restore voiding in women with Fowler's syndrome is sacral neuromodulation. Sphincter injections of botulinum toxin are a possible outpatient‐based alternative. / Learning objectives: To review the typical symptoms and signs associated with Fowler's syndrome. To share the current understanding about why this condition may occur. To understand how to evaluate and treat a woman with suspected Fowler's syndrome. / Ethical issues: Fowler's syndrome should be considered in women presenting with urinary retention where the cause for retention is uncertain.

Type: Article
Title: Fowler's syndrome: a primary disorder of urethral sphincter relaxation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/tog.12448
Publisher version: https://doi.org/10.1111/tog.12448
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: botulinum toxin, electromyography, Fowler's syndrome, sacral neuromodulation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1569199
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