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Phase and morphological control of MoO3-x nanostructures for efficient cancer theragnosis therapy

Li, B; Wang, X; Wu, X; He, G; Xu, R; Lu, X; Wang, FR; (2017) Phase and morphological control of MoO3-x nanostructures for efficient cancer theragnosis therapy. Nanoscale , 9 (31) pp. 11012-11016. 10.1039/c7nr03469e. Green open access

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Abstract

Nanostructures of metal oxide semiconductors play significant roles in a variety of areas, such as biotherapy, pollutant treatment and energy storage and conversion. The molybdenum oxide (MoO3−x) nanostructures have shown promising applications especially when used as photothermal treatment agents due to their relatively low cost, facile synthesis and low toxicity. However, the design and synthesis of efficient MoO3−x nanomaterials with tunable phases and morphologies for theragnosis of tumors remains a challenge. In this work, hydrophilic MoO3−x with controlled structures and phases was synthesized by a simple one-step hydrothermal process. The as-obtained MoO2 nanoclusters showed a desirable size of ∼40 nm in diameter exhibiting unique properties as a theragnosis nanoplatform: (1) strong near-infrared absorption, which is due to oxygen vacancies of the nanoclusters, as proved by photoluminescence spectroscopy and X-ray photoelectron spectroscopy; (2) excellent photothermal performance with a photothermal conversion efficiency of up to 62.1%; and (3) the image response of X-ray computed tomography (CT) and infrared thermal imaging for simultaneous diagnosis of tumors. This study provided the facile synthetic strategy for controllable metal oxide semiconductors and promoted the development of metal oxides for theragnosis therapy of cancers.

Type: Article
Title: Phase and morphological control of MoO3-x nanostructures for efficient cancer theragnosis therapy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c7nr03469e
Publisher version: http://dx.doi.org/10.1039/c7nr03469e
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Keywords: Science & Technology, Physical Sciences, Technology, Chemistry, Multidisciplinary, Nanoscience & Nanotechnology, Materials Science, Multidisciplinary, Physics, Applied, Chemistry, Science & Technology - Other Topics, Materials Science, Physics, 980 nm-laser, Driven Photothermal Agent, Drug-Delivery, In-Vivo, Cells, Nanoparticles, Nanocrystals, Ablation, Nanomaterials, Performance
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1568674
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